Andrea Domenighetti, PhD

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My Lab

Our research group specializes in utilizing techniques from molecular and cell biology, genetics, and various experimental models. Our focus is on identifying new biomarkers and potential molecules to support rehabilitation in patients with neurological and neuromuscular conditions.

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About Me

I have 15 years of post-graduate experience in developing, running and managing research projects in cellular, molecular & tissue biology for academic and healthcare Institutes worldwide. Over the years I have investigated molecular & cellular biomarkers and supported translational research approaches for the development of new therapeutics for chronic conditions, including cardiovascular, renal, neuromuscular and neurological. I use tools from molecular & cell biology, genetics and other experimental models, to identify new biomarkers and drugs that could support rehabilitation in patients with neurological or neuromuscular conditions. My lab is fully integrated into the Biologics Lab at the SRAlab and the PM&R Department at Northwestern University.

Location

Shirley Ryan AbilityLab

26th Floor

355 East Erie

Chicago, IL 60611

Education & Training

Education & Training

1994 – 1998

Biology, University of Geneva - Switzerland

1999 – 2004

Physiology, University of Melbourne - Australia

2005 – 2006

Pharmacology & Toxicology, University of Lausanne - Switzerland

2007 – 2011

Cardiology, University of California in San Diego - USA

2011 – 2015

Orthopedic Surgery, University of California in San Diego - USA

Recent Publications

Loss of myogenic potential and fusion capacity of muscle stem cells isolated from contractured muscle in children with cerebral palsy.

Domenighetti AA, Mathewson MA, Pichika R, Sibley LA, Zhao L, Chambers HG, Lieber RL

American journal of physiology. Cell physiology

doi: 10.1152/ajpcell.00351.2017

Management of Cardiac Involvement Associated With Neuromuscular Diseases: A Scientific Statement From the American Heart Association.

Feingold B, Mahle WT, Auerbach S, Clemens P, Domenighetti AA, Jefferies JL, Judge DP, Lal AK, Markham LW, Parks WJ, Tsuda T, Wang PJ, Yoo SJ, American Heart Association Pediatric Heart Failure Committee of the Council on Cardiovascular Disease in the Young; Council on Clinical Cardiology; Council on Cardiovascular Radiology and Intervention; Council on Functional Genomics and Translational Biology; and Stroke Council

Circulation

doi: 10.1161/CIR.0000000000000526

Cullin E3 Ligase Activity Is Required for Myoblast Differentiation.

Blondelle J, Shapiro P, Domenighetti AA, Lange S

Journal of molecular biology

doi: 10.1016/j.jmb.2017.02.012

Honors & Awards

Research fellowship
Roche Research Foundation, 1999
International Postgraduate Research Scholarship (IPRS) and Melbourne International Research Scholarship (MIRS)
The University of Melbourne, 2000
Young Researcher/Doctoral fellowship
Swiss National Science Foundation, 2000
W.G. Nayler Prize
International Society for Heart Research, 2002

Excellence Award in Cardiovascular Research
Pfizer - Switzerland, 2007
Advanced postdoctoral fellowship
Swiss National Science Foundation, Switzerland, 2006
HALO "Heroes of Medicine" Awards
For “discovering that an already approved drug used to treat a form of blood cancer may help treat or cure muscle contractures in children with cerebral palsy’, Chicago, IL, 2018