Muscle Physiology Lab : Publications

Effects of voluntary exercise on muscle structure and function in cerebral palsy.

Moreau NG, Lieber RL
Developmental medicine and child neurology

An estrogen-sensitive fibroblast population drives abdominal muscle fibrosis in an inguinal hernia mouse model.

Potluri T, Taylor MJ, Stulberg JJ, Lieber RL, Zhao H, Bulun SE
JCI insight

Procedures for obtaining muscle physiology parameters during a gracilis free-functioning muscle transfer in adult patients with brachial plexus injury.

Persad LS, Ates F, Evertz LQ, Litchy WJ, Lieber RL, Kaufman KR, Shin AY
Scientific reports

Teamwork Pays! Ten Tips for a Great Surgeon-Scientist Collaboration.

Lieber RL, Fridén J
The Journal of hand surgery

Can we just forget about pennation angle?

Lieber RL
Journal of biomechanics

Starting at Birth: An Integrative, State-of-the-Science Framework for Optimizing Infant Neuromotor Health.

Peyton C, Sukal Moulton T, Carroll AJ, Anderson E, Brozek A, Davis MM, Horowitz J, Jayaraman A, O'Brien M, Patrick C, Pouppirt N, Villamar J, Xu S, Lieber RL, Wakschlag LS, Krogh-Jespersen S
Frontiers in pediatrics

Systematic review of skeletal muscle passive mechanics experimental methodology.

Binder-Markey BI, Sychowski D, Lieber RL
Journal of biomechanics

Miniaturized wireless, skin-integrated sensor networks for quantifying full-body movement behaviors and vital signs in infants.

Jeong H, Kwak SS, Sohn S, Lee JY, Lee YJ, O'Brien MK, Park Y, Avila R, Kim JT, Yoo JY, Irie M, Jang H, Ouyang W, Shawen N, Kang YJ, Kim SS, Tzavelis A, Lee K, Andersen RA, Huang Y, Jayaraman A, Davis MM, Shanley T, Wakschlag LS, Krogh-Jespersen S, Xu S, Ryan SW, Lieber RL, Rogers JA
Proceedings of the National Academy of Sciences of the United States of America

Differential DNA methylation and transcriptional signatures characterize impairment of muscle stem cells in pediatric human muscle contractures after brain injury.

Sibley LA, Broda N, Gross WR, Menezes AF, Embry RB, Swaroop VT, Chambers HG, Schipma MJ, Lieber RL, Domenighetti AA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Skeletal muscle maximal mitochondrial activity in ambulatory children with cerebral palsy.

Dayanidhi S, Buckner EH, Redmond RS, Chambers HG, Schenk S, Lieber RL
Developmental medicine and child neurology

Stretch-induced satellite cell deformation incontracturedmuscles in children with cerebral palsy.

Dykstra PB, Dayanidhi S, Chambers HG, Lieber RL
Journal of biomechanics

Stretch-induced satellite cell deformation incontracturedmuscles in children with cerebral palsy.

Dykstra PB, Dayanidhi S, Chambers HG, Lieber RL
Journal of Biomechanics

In vivo human gracilis whole-muscle passive stress-sarcomere strain relationship.

Persad LS, Binder-Markey BI, Shin AY, Kaufman KR, Lieber RL
The Journal of experimental biology

In vivo human gracilis whole-muscle passive stress-sarcomere strain relationship.

Persad LS, Binder-Markey BI, Shin AY, Kaufman KR, Lieber RL
The Journal of experimental biology

Measuring and modeling in vivo human gracilis muscle-tendon unit length.

Persad LS, Ates F, Shin AY, Lieber RL, Kaufman KR
Journal of biomechanics

Measuring and modeling in vivo human gracilis muscle-tendon unit length.

Persad LS, Ates F, Shin AY, Lieber RL, Kaufman KR
Journal of Biomechanics

Outcome from a brachialis donor for wrist extension in tetraplegia-time to reconsider the International Classification for Surgery of the Hand in Tetraplegia (ICSHT).

Fridén J, Son J, Koch-Borner S, Lieber RL
Spinal cord series and cases

Outcome from a brachialis donor for wrist extension in tetraplegia-time to reconsider the International Classification for Surgery of the Hand in Tetraplegia (ICSHT).

Fridén J, Son J, Koch-Borner S, Lieber RL
Spinal cord series and cases

Muscle-tendon unit in children with cerebral palsy.

Lieber RL, Theologis T
Developmental medicine and child neurology

Biochemical and structural basis of the passive mechanical properties of whole skeletal muscle.

Lieber RL, Binder-Markey BI
The Journal of physiology

Biochemical and structural basis of the passive mechanical properties of whole skeletal muscle.

Lieber RL, Binder-Markey BI
The Journal of physiology

Systemic transplantation of adult multipotent stem cells prevents articular cartilage degeneration in a mouse model of accelerated ageing.

Thompson SD, Pichika R, Lieber RL, Lavasani M
Immunity & ageing : I & A

Systemic transplantation of adult multipotent stem cells prevents articular cartilage degeneration in a mouse model of accelerated ageing.

Thompson SD, Pichika R, Lieber RL, Lavasani M
Immunity & ageing : I & A

A Mobility Measure for Inpatient Rehabilitation Using Multigroup, Multidimensional Methods.

Deom CE, Carpenter J, Bodine AJ, Taylor SM, Heinemann AW, Lieber RL, Sliwa JA
Journal of Neurologic Physical Therapy

The Lumbricals Are Not the Workhorse of Digital Extension and Do Not Relax Their Own Antagonist.

Crowley JS, Meunier M, Lieber RL, Abrams RA
The Journal of Hand Surgery

Characterization of Motor-Evoked Responses Obtained with Transcutaneous Electrical Spinal Stimulation from the Lower-Limb Muscles after Stroke.

Moon Y, Zuleger T, Lamberti M, Bansal A, Mummidisetty CK, McKenzie KA, Yingling L, Madhavan S, Roth EJ, Lieber RL, Jayaraman A
Brain sciences

Commentary: Muscle Microbiopsy to Delineate Stem Cell Involvement in Young Patients: A Novel Approach for Children With Cerebral Palsy.

Lieber RL, Domenighetti AA
Frontiers in physiology

Skeletal muscle maximal mitochondrial activity in ambulatory children with cerebral palsy.

Dayanidhi S, Buckner EH, Redmond RS, Chambers HG, Schenk S, Lieber RL
Developmental Medicine & Child Neurology

Development of a Multidimensional, Multigroup Measure of Self-Care for Inpatient Rehabilitation.

Bodine AJ, Heinemann AW, Carpenter J, Taylor SM, Hansen P, Lieber RL, Sliwa J
Archives of Physical Medicine and Rehabilitation

In vivo supraspinatus muscle contractility and architecture in rabbit.

Hyman SA, Norman MB, Dorn SN, Bremner SN, Esparza MC, Lieber RL, Ward SR
Journal of Applied Physiology

Vitamin D ameliorates adipose browning in chronic kidney disease cachexia.

Cheung WW, Ding W, Hoffman HM, Wang Z, Hao S, Zheng R, Gonzalez A, Zhan JY, Zhou P, Li S, Esparza MC, Lieber RL, Mak RH
Scientific reports

Inpatient stroke rehabilitation: prediction of clinical outcomes using a machine-learning approach.

Harari Y, O'Brien MK, Lieber RL, Jayaraman A
Journal of neuroengineering and rehabilitation

Intramuscular Anatomy Drives Collagen Content Variation Within and Between Muscles.

Binder-Markey BI, Broda NM, Lieber RL
Frontiers in physiology

Pragmatic adaptation of implementation research measures for a novel context and multiple professional roles: a factor analysis study.

Smith JD, Rafferty MR, Heinemann AW, Meachum MK, Villamar J, Lieber RL, Brown CH
BMC health services research

Non-linear Scaling of Passive Mechanical Properties in Fibers, Bundles, Fascicles and Whole Rabbit Muscles.

Ward SR, Winters TM, O'Connor SM, Lieber RL
Frontiers in physiology

Myopalladin promotes muscle growth through modulation of the serum response factor pathway.

Filomena MC, Yamamoto DL, Caremani M, Kadarla VK, Mastrototaro G, Serio S, Vydyanath A, Mutarelli M, Garofalo A, Pertici I, Knöll R, Nigro V, Luther PK, Lieber RL, Beck MR, Linari M, Bang ML
Journal of cachexia, sarcopenia and muscle

Myopalladin promotes muscle growth through modulation of the serum response factor pathway.

Filomena MC, Yamamoto DL, Caremani M, Kadarla VK, Mastrototaro G, Serio S, Vydyanath A, Mutarelli M, Garofalo A, Pertici I, Knöll R, Nigro V, Luther PK, Lieber RL, Beck MR, Linari M, Bang ML
Journal of cachexia, sarcopenia and muscle

Automating sleep stage classification using wireless, wearable sensors.

Boe AJ, McGee Koch LL, O'Brien MK, Shawen N, Rogers JA, Lieber RL, Reid KJ, Zee PC, Jayaraman A
NPJ digital medicine

Architecture of the Short External Rotator Muscles of the Hip.

Parvaresh KC, Chang C, Patel A, Lieber RL, Ball ST, Ward SR
BMC musculoskeletal disorders

Contribution of extracellular matrix components to the stiffness of skeletal muscle contractures in patients with cerebral palsy.

Smith LR, Pichika R, Meza RC, Gillies AR, Baliki MN, Chambers HG, Lieber RL
Connective tissue research

Muscle contracture and passive mechanics in cerebral palsy.

Lieber RL, Fridén J
Journal of applied physiology (Bethesda, Md. : 1985)

Reach out and grasp the opportunity: reconstructive hand surgery in tetraplegia.

Fridén J, Lieber RL
Journal of Hand Surgery (European Volume)

Design Considerations of a Fiber Optic Pressure Sensor Protective Housing for Intramuscular Pressure Measurements.

Go SA, Jensen ER, O'Connor SM, Evertz LQ, Morrow DA, Ward SR, Lieber RL, Kaufman KR
Annals of biomedical engineering

In Vivo Sarcomere Length Measurement in Whole Muscles during Passive Stretch and Twitch Contractions.

Young KW, Kuo BP, O'Connor SM, Radic S, Lieber RL
Biophysical journal

High resolution three-dimensional reconstruction of fibrotic skeletal muscle extracellular matrix.

Gillies AR, Chapman MA, Bushong EA, Deerinck TJ, Ellisman MH, Lieber RL
The Journal of physiology

Skeletal muscle fiber-type specific succinate dehydrogenase activity in cerebral palsy.

Zogby AM, Dayanidhi S, Chambers HG, Schenk S, Lieber RL
Muscle & nerve

Three Distinct Cell Populations Express Extracellular Matrix Proteins and Increase in Number During Skeletal Muscle Fibrosis.

Chapman MA, Mukund K, Subramaniam S, Brenner D, Lieber RL
American journal of physiology. Cell physiology

Impact of vaginal parity and aging on the architectural design of pelvic floor muscles.

Alperin M, Cook M, Tuttle LJ, Esparza MC, Lieber RL
American journal of obstetrics and gynecology

Reduced skeletal muscle satellite cell number alters muscle morphology after chronic stretch but allows limited serial sarcomere addition.

Kinney MC, Dayanidhi S, Dykstra PB, McCarthy JJ, Peterson CA, Lieber RL
Muscle & nerve

Quantification of sarcomere length distribution in whole muscle frozen sections.

O'Connor SM, Cheng EJ, Young KW, Ward SR, Lieber RL
The Journal of experimental biology

Muscle wasting and adipose tissue browning in infantile nephropathic cystinosis.

Cheung WW, Cherqui S, Ding W, Esparza M, Zhou P, Shao J, Lieber RL, Mak RH
Journal of cachexia, sarcopenia and muscle

Cerebral palsy.

Graham HK, Rosenbaum P, Paneth N, Dan B, Lin JP, Damiano DL, Becher JG, Gaebler-Spira D, Colver A, Reddihough DS, Crompton KE, Lieber RL
Nature Reviews Disease Primers

Dramatic changes in muscle contractile and structural properties after 2 botulinum toxin injections.

Minamoto VB, Suzuki KP, Bremner SN, Lieber RL, Ward SR
Muscle & nerve

Lmo7 is dispensable for skeletal muscle and cardiac function.

Lao DH, Esparza MC, Bremner SN, Banerjee I, Zhang J, Veevers J, Bradford WH, Gu Y, Dalton ND, Knowlton KU, Peterson KL, Lieber RL, Chen J
American journal of physiology. Cell physiology

Pregnancy-induced adaptations in the intrinsic structure of rat pelvic floor muscles.

Alperin M, Lawley DM, Esparza MC, Lieber RL
American journal of obstetrics and gynecology

Reduced satellite cell number in situ in muscular contractures from children with cerebral palsy.

Dayanidhi S, Dykstra PB, Lyubasyuk V, McKay BR, Chambers HG, Lieber RL
Journal of Orthopaedic Research

The mechanical strength of side-to-side tendon repair with mismatched tendon size and shape.

Fridén J, Tirrell TF, Bhola S, Lieber RL
The Journal of hand surgery, European volume

Collagen crosslinking does not dictate stiffness in a transgenic mouse model of skeletal muscle fibrosis.

Chapman MA, Pichika R, Lieber RL
Journal of biomechanics

Skeletal muscle intermediate filaments form a stress-transmitting and stress-signaling network.

Palmisano MG, Bremner SN, Hornberger TA, Meyer GA, Domenighetti AA, Shah SB, Kiss B, Kellermayer M, Ryan AF, Lieber RL
Journal of cell science

The effect of intrinsic loading and reconstruction upon grip capacity and finger extension kinematics.

Muzykewicz DA, Arnet U, Fridén J, Lieber RL
The Journal of Hand Surgery

High resolution muscle measurements provide insights into equinus contractures in patients with cerebral palsy.

Mathewson MA, Ward SR, Chambers HG, Lieber RL
Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Stiff muscle fibers in calf muscles of patients with cerebral palsy lead to high passive muscle stiffness.

Mathewson MA, Chambers HG, Girard PJ, Tenenhaus M, Schwartz AK, Lieber RL
Journal of Orthopaedic Research

Three-dimensional reconstruction of skeletal muscle extracellular matrix ultrastructure.

Gillies AR, Bushong EA, Deerinck TJ, Ellisman MH, Lieber RL
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

Resonant reflection spectroscopy of biomolecular arrays in muscle.

Young KW, Radic S, Myslivets E, O'Connor SM, Lieber RL
Biophysical journal

Disruption of both nesprin 1 and desmin results in nuclear anchorage defects and fibrosis in skeletal muscle.

Chapman MA, Zhang J, Banerjee I, Guo LT, Zhang Z, Shelton GD, Ouyang K, Lieber RL, Chen J
Human molecular genetics

Systems analysis of transcriptional data provides insights into muscle's biological response to botulinum toxin.

Mukund K, Mathewson M, Minamoto V, Ward SR, Subramaniam S, Lieber RL
Muscle & nerve

Comparison of pelvic muscle architecture between humans and commonly used laboratory species.

Alperin M, Tuttle LJ, Conner BR, Dixon DM, Mathewson MA, Ward SR, Lieber RL
International urogynecology journal

Polarization gating enables sarcomere length measurements by laser diffraction in fibrotic muscle.

Young KW, Dayanidhi S, Lieber RL
Journal of biomedical optics

Effect of supraspinatus tendon injury on supraspinatus and infraspinatus muscle passive tension and associated biochemistry.

Silldorff MD, Choo AD, Choi AJ, Lin E, Carr JA, Lieber RL, Lane JG, Ward SR
The Journal of bone and joint surgery. American volume

Muscle gene expression patterns in human rotator cuff pathology.

Choo A, McCarthy M, Pichika R, Sato EJ, Lieber RL, Schenk S, Lane JG, Ward SR
The Journal of bone and joint surgery. American volume

Systematic test of neurotoxin dose and volume on muscle function in a rat model.

Hulst JB, Minamoto VB, Lim MB, Bremner SN, Ward SR, Lieber RL
Muscle & nerve

Post-mortem timing of skeletal muscle biochemical and mechanical degradation.

Tuttle LJ, Alperin M, Lieber RL
Journal of biomechanics

Contribution of denervated muscle to contractures after neonatal brachial plexus injury: not just muscle fibrosis.

Nikolaou S, Liangjun H, Tuttle LJ, Weekley H, Christopher W, Lieber RL, Cornwall R
Muscle & Nerve

Architectural design of the pelvic floor is consistent with muscle functional subspecialization.

Tuttle LJ, Nguyen OT, Cook MS, Alperin M, Shah SB, Ward SR, Lieber RL
International urogynecology journal

Comparison of rotator cuff muscle architecture between humans and other selected vertebrate species.

Mathewson MA, Kwan A, Eng CM, Lieber RL, Ward SR
The Journal of experimental biology

Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice.

Domenighetti AA, Chu PH, Wu T, Sheikh F, Gokhin DS, Guo LT, Cui Z, Peter AK, Christodoulou DC, Parfenov MG, Gorham JM, Li DY, Banerjee I, Lai X, Witzmann FA, Seidman CE, Seidman JG, Gomes AV, Shelton GD, Lieber RL, Chen J
Human molecular genetics

The nebulin SH3 domain is dispensable for normal skeletal muscle structure but is required for effective active load bearing in mouse.

Yamamoto DL, Vitiello C, Zhang J, Gokhin DS, Castaldi A, Coulis G, Piaser F, Filomena MC, Eggenhuizen PJ, Kunderfranco P, Camerini S, Takano K, Endo T, Crescenzi M, Luther PK, Lieber RL, Chen J, Bang ML
Journal of cell science

Intrinsic hand muscle function, part 1: creating a functional grasp.

Arnet U, Muzykewicz DA, Fridén J, Lieber RL
The Journal of hand surgery

Intrinsic hand muscle function, part 2: kinematic comparison of 2 reconstructive procedures.

Muzykewicz DA, Arnet U, Lieber RL, Fridén J
The Journal of hand surgery

Functional consequence of distal brachioradialis tendon release: a biomechanical study.

Tirrell TF, Franko OI, Bhola S, Hentzen ER, Abrams RA, Lieber RL
The Journal of hand surgery

Role of the cytoskeleton in muscle transcriptional responses to altered use.

Meyer GA, Schenk S, Lieber RL
Physiological genomics

Reduced satellite cell population may lead to contractures in children with cerebral palsy.

Smith LR, Chambers HG, Lieber RL
Developmental medicine and child neurology

Anatomical, architectural, and biochemical diversity of the murine forelimb muscles.

Mathewson MA, Chapman MA, Hentzen ER, Fridén J, Lieber RL
Journal of anatomy

Muscle excursion does not correlate with increased serial sarcomere number after muscle adaptation to stretched tendon transfer.

Takahashi M, Ward SR, Fridén J, Lieber RL
Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Human skeletal muscle biochemical diversity.

Tirrell TF, Cook MS, Carr JA, Lin E, Ward SR, Lieber RL
The Journal of experimental biology

Passive mechanical properties of rat abdominal wall muscles suggest an important role of the extracellular connective tissue matrix.

Brown SH, Carr JA, Ward SR, Lieber RL
Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Skeletal muscle fibrosis develops in response to desmin deletion.

Meyer GA, Lieber RL
American journal of physiology. Cell physiology

Sample size considerations in human muscle architecture studies.

Tuttle LJ, Ward SR, Lieber RL
Muscle & nerve

Simultaneous powering of forearm pronation and key pinch in tetraplegia using a single muscle-tendon unit.

Fridén J, Reinholdt C, Gohritz A, Peace WJ, Ward SR, Lieber RL
The Journal of hand surgery, European volume

Passive mechanical properties and related proteins change with botulinum neurotoxin A injection of normal skeletal muscle.

Thacker BE, Tomiya A, Hulst JB, Suzuki KP, Bremner SN, Gastwirt RF, Greaser ML, Lieber RL, Ward SR
Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Transcriptional abnormalities of hamstring muscle contractures in children with cerebral palsy.

Smith LR, Chambers HG, Subramaniam S, Lieber RL
PloS one

Psoas muscle architectural design, in vivo sarcomere length range, and passive tensile properties support its role as a lumbar spine stabilizer.

Regev GJ, Kim CW, Tomiya A, Lee YP, Ghofrani H, Garfin SR, Lieber RL, Ward SR
Spine

Sustained improvement in the anal sphincter function following surgical plication of rabbit external anal sphincter muscle.

Rajasekaran MR, Jiang Y, Bhargava V, Ramamoorthy S, Lieber RL, Mittal RK
Diseases of the Colon & Rectum

ISSLS prize winner: Adaptations to the multifidus muscle in response to experimentally induced intervertebral disc degeneration.

Brown SH, Gregory DE, Carr JA, Ward SR, Masuda K, Lieber RL
Spine

A nonlinear model of passive muscle viscosity.

Meyer GA, McCulloch AD, Lieber RL
Journal of biomechanical engineering

Moment arms of the human digital flexors.

Franko OI, Winters TM, Tirrell TF, Hentzen ER, Lieber RL
Journal of biomechanics

The external anal sphincter operates at short sarcomere length in humans.

Mittal RK, Sheean G, Padda BS, Lieber R, Raj Rajasekaran M
Neurogastroenterology & Motility

The external anal sphincter operates at short sarcomere length in humans.

Mittal RK, Sheean G, Padda BS, Lieber R, Raj Rajasekaran M
Neurogastroenterology & Motility

Muscle extracellular matrix applies a transverse stress on fibers with axial strain.

Smith LR, Fowler-Gerace LH, Lieber RL
Journal of biomechanics

Hamstring contractures in children with spastic cerebral palsy result from a stiffer extracellular matrix and increased in vivo sarcomere length.

Smith LR, Lee KS, Ward SR, Chambers HG, Lieber RL
The Journal of physiology

Method for decellularizing skeletal muscle without detergents or proteolytic enzymes.

Gillies AR, Smith LR, Lieber RL, Varghese S
Tissue engineering. Part C, Methods

Quantification of partial or complete A4 pulley release with FDP repair in cadaveric tendons.

Franko OI, Lee NM, Finneran JJ, Shillito MC, Meunier MJ, Abrams RA, Lieber RL
The Journal of hand surgery

Architectural analysis of human abdominal wall muscles: implications for mechanical function.

Brown SH, Ward SR, Cook MS, Lieber RL
Spine

Elucidation of extracellular matrix mechanics from muscle fibers and fiber bundles.

Meyer GA, Lieber RL
Journal of biomechanics

Whole muscle length-tension relationships are accurately modeled as scaled sarcomeres in rabbit hindlimb muscles.

Winters TM, Takahashi M, Lieber RL, Ward SR
Journal of biomechanics

Novel applications of external anal sphincter muscle sarcomere length to enhance the anal canal function.

Rajasekaran MR, Jiang Y, Bhargava V, Lieber RL, Mittal RK
Neurogastroenterology & Motility

Plasticity of muscle architecture after supraspinatus tears.

Ward SR, Sarver JJ, Eng CM, Kwan A, Würgler-Hauri CC, Perry SM, Williams GR, Soslowsky LJ, Lieber RL
The Journal of orthopaedic and sports physical therapy

Mechanical feasibility of immediate mobilization of the brachioradialis muscle after tendon transfer.

Fridén J, Shillito MC, Chehab EF, Finneran JJ, Ward SR, Lieber RL
The Journal of hand surgery

Architectural and morphological assessment of rat abdominal wall muscles: comparison for use as a human model.

Brown SH, Banuelos K, Ward SR, Lieber RL
Journal of anatomy

Regional Myosin heavy chain distribution in selected paraspinal muscles.

Regev GJ, Kim CW, Thacker BE, Tomiya A, Garfin SR, Ward SR, Lieber RL
Spine

Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology.

Gokhin DS, Lewis RA, McKeown CR, Nowak RB, Kim NE, Littlefield RS, Lieber RL, Fowler VM
The Journal of cell biology

Mechanical strength of the side-to-side versus Pulvertaft weave tendon repair.

Brown SH, Hentzen ER, Kwan A, Ward SR, Fridén J, Lieber RL
The Journal of hand surgery

Asynchronous muscle and tendon adaptation after surgical tensioning procedures.

Takahashi M, Ward SR, Marchuk LL, Frank CB, Lieber RL
The Journal of bone and joint surgery. American volume

A model of the lower limb for analysis of human movement.

Arnold EM, Ward SR, Lieber RL, Delp SL
Annals of biomedical engineering

Theoretical predictions of the effects of force transmission by desmin on intersarcomere dynamics.

Meyer GA, Kiss B, Ward SR, Morgan DL, Kellermayer MS, Lieber RL
Biophysical journal

Nesprin 1 is critical for nuclear positioning and anchorage.

Zhang J, Felder A, Liu Y, Guo LT, Lange S, Dalton ND, Gu Y, Peterson KL, Mizisin AP, Shelton GD, Lieber RL, Chen J
Human molecular genetics

Nebulin plays a direct role in promoting strong actin-myosin interactions.

Bang ML, Caremani M, Brunello E, Littlefield R, Lieber RL, Chen J, Lombardi V, Linari M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Obscurin determines the architecture of the longitudinal sarcoplasmic reticulum.

Lange S, Ouyang K, Meyer G, Cui L, Cheng H, Lieber RL, Chen J
Journal of cell science

Passive mechanical properties of the lumbar multifidus muscle support its role as a stabilizer.

Ward SR, Tomiya A, Regev GJ, Thacker BE, Benzl RC, Kim CW, Lieber RL
Journal of biomechanics

Correlation between isometric force and intramuscular pressure in rabbit tibialis anterior muscle with an intact anterior compartment.

Winters TM, Sepulveda GS, Cottler PS, Kaufman KR, Lieber RL, Ward SR
Muscle & nerve

Reduced thin filament length in nebulin-knockout skeletal muscle alters isometric contractile properties.

Gokhin DS, Bang ML, Zhang J, Chen J, Lieber RL
American journal of physiology. Cell physiology

Acceptable benefits and risks associated with surgically improving arm function in individuals living with cervical spinal cord injury.

Anderson KD, Fridén J, Lieber RL
Spinal Cord

Are current measurements of lower extremity muscle architecture accurate?

Ward SR, Eng CM, Smallwood LH, Lieber RL
Clinical orthopaedics and related research

Architectural analysis and intraoperative measurements demonstrate the unique design of the multifidus muscle for lumbar spine stability.

Ward SR, Kim CW, Eng CM, Gottschalk LJ 4th, Tomiya A, Garfin SR, Lieber RL
The Journal of bone and joint surgery. American volume

Muscle injury, vimentin expression, and nonsteroidal anti-inflammatory drugs predispose to cryptic group A streptococcal necrotizing infection.

Hamilton SM, Bayer CR, Stevens DL, Lieber RL, Bryant AE
The Journal of Infectious Diseases

Scaling of muscle architecture and fiber types in the rat hindlimb.

Eng CM, Smallwood LH, Rainiero MP, Lahey M, Ward SR, Lieber RL
Journal of Experimental Biology

Quantitative analysis of neonatal skeletal muscle functional improvement in the mouse.

Gokhin DS, Ward SR, Bremner SN, Lieber RL
Journal of Experimental Biology

Increased efficacy and decreased systemic-effects of botulinum toxin A injection after active or passive muscle manipulation.

Minamoto VB, Hulst JB, Lim M, Peace WJ, Bremner SN, Ward SR, Lieber RL

Relationship between muscle stress and intramuscular pressure during dynamic muscle contractions.

Ward SR, Davis J, Kaufman KR, Lieber RL

Intraoperative muscle measurements reveal a relationship between contracture formation and muscle remodeling.

Pontén E, Gantelius S, Lieber RL

Structural and regulatory roles of muscle ankyrin repeat protein family in skeletal muscle.

Barash IA, Bang ML, Mathew L, Greaser ML, Chen J, Lieber RL

Intraoperative single-site sarcomere length measurement accurately reflects whole-muscle sarcomere length in the rabbit.

Takahashi M, Ward SR, Lieber RL

Muscle adaptation by serial sarcomere addition 1 year after femoral lengthening.

Boakes JL, Foran J, Ward SR, Lieber RL

High stiffness of human digital flexor tendons is suited for precise finger positional control.

Ward SR, Loren GJ, Lundberg S, Lieber RL

Variability in surgical technique for brachioradialis tendon transfer. Evidence and implications.

Murray WM, Hentz VR, Fridén J, Lieber RL

Passive muscle-tendon amplitude may not reflect skeletal muscle functional excursion.

Fridén J, Ward SR, Smallwood L, Lieber RL

Rotator cuff muscle architecture: implications for glenohumeral stability.

Ward SR, Hentzen ER, Smallwood LH, Eastlack RK, Burns KA, Fithian DC, Friden J, Lieber RL

Dorsal transfer of the brachioradialis to the flexor pollicis longus enables simultaneous powering of key pinch and forearm pronation.

Ward SR, Peace WJ, Fridén J, Lieber RL

Density and hydration of fresh and fixed human skeletal muscle.

Ward SR, Lieber RL

Muscle LIM protein plays both structural and functional roles in skeletal muscle.

Barash IA, Mathew L, Lahey M, Greaser ML, Lieber RL

Pronator teres is an appropriate donor muscle for restoration of wrist and thumb extension.

Abrams GD, Ward SR, Fridén J, Lieber RL

Sarcomere length measurement permits high resolution normalization of muscle fiber length in architectural studies.

Felder A, Ward SR, Lieber RL

Spastic wrist flexors are more severely affected than wrist extensors in children with cerebral palsy.

Pontén E, Fridén J, Thornell LE, Lieber RL

Biomechanical properties of the brachioradialis muscle: Implications for surgical tendon transfer.

Lieber RL, Murray WM, Clark DL, Hentz VR, Fridén J

Sarcomere strain and heterogeneity correlate with injury to frog skeletal muscle fiber bundles.

Patel TJ, Das R, Fridén J, Lutz GJ, Lieber RL

Fiber length variability within the flexor carpi ulnaris and flexor carpi radialis muscles: implications for surgical tendon transfer.

Fridén J, Lovering RM, Lieber RL

Predicted effects of metacarpal shortening on interosseous muscle function.

Meunier MJ, Hentzen E, Ryan M, Shin AY, Lieber RL

Rapid muscle-specific gene expression changes after a single bout of eccentric contractions in the mouse.

Barash IA, Mathew L, Ryan AF, Chen J, Lieber RL

Inferior mechanical properties of spastic muscle bundles due to hypertrophic but compromised extracellular matrix material.

Lieber RL, Runesson E, Einarsson F, Fridén J

Analysis of posterior deltoid function one year after surgical restoration of elbow extension.

Lieber RL, Fridén J, Hobbs T, Rothwell AG

Spastic muscle cells are shorter and stiffer than normal cells.

Fridén J, Lieber RL

Performance characteristics of a pressure microsensor.

Kaufman KR, Wavering T, Morrow D, Davis J, Lieber RL

Simultaneous imaging and functional assessment of cytoskeletal protein connections in passively loaded single muscle cells.

Shah SB, Lieber RL

Finite element model of intramuscular pressure during isometric contraction of skeletal muscle.

Jenkyn TR, Koopman B, Huijing P, Lieber RL, Kaufman KR

Desmin cytoskeletal modifications after a bout of eccentric exercise in the rat.

Barash IA, Peters D, Fridén J, Lutz GJ, Lieber RL

In vitro cyclic tensile testing of combined peripheral and core flexor tenorrhaphy suture techniques.

Tran HN, Cannon DL, Lieber RL, Abrams RA

Influence of myosin isoforms on contractile properties of intact muscle fibers from Rana pipiens.

Lutz GJ, Sirsi SR, Shapard-Palmer SA, Bremner SN, Lieber RL

Differential expression of neural cell adhesion molecule (NCAM) after tenotomy in rabbit skeletal muscle.

Jamali AA, Afshar P, Abrams RA, Lieber RL

Spasticity causes a fundamental rearrangement of muscle-joint interaction.

Lieber RL, Fridén J

Evidence for increased myofibrillar mobility in desmin-null mouse skeletal muscle.

Shah SB, Su FC, Jordan K, Milner DJ, Fridén J, Capetanaki Y, Lieber RL

Identification of myosin light chains in Rana pipiens skeletal muscle and their expression patterns along single fibres.

Lutz GJ, Bremner SN, Bade MJ, Lieber RL

Sarcomere number regulation maintained after immobilization in desmin-null mouse skeletal muscle.

Shah SB, Peters D, Jordan KA, Milner DJ, Fridén J, Capetanaki Y, Lieber RL

Serum creatine kinase level is a poor predictor of muscle function after injury.

Fridén J, Lieber RL

Biomechanical analysis of the brachioradialis as a donor in tendon transfer.

Fridén J, Albrecht D, Lieber RL

Quantitative evaluation of the posterior deltoid to triceps tendon transfer based on muscle architectural properties.

Fridén J, Lieber RL

Desmin knockout muscles generate lower stress and are less vulnerable to injury compared with wild-type muscles.

Sam M, Shah S, Fridén J, Milner DJ, Capetanaki Y, Lieber RL

Interaction between series compliance and sarcomere kinetics determines internal sarcomere shortening during fixed-end contraction.

Kawakami Y, Lieber RL

Multiquadrant digital analysis of shoulder capsular thickness.

Ciccone WJ 2nd, Hunt TJ, Lieber R, Pedowitz R, Esch J, Tasto JP

Cloning and characterization of the S1 domain of four myosin isoforms from functionally divergent fiber types in adult Rana pipiens skeletal muscle.

Lutz GJ, Razzaghi S, Lieber RL

Skeletal muscle recovery after tenotomy and 7-day delayed muscle length restoration.

Abrams RA, Tsai AM, Watson B, Jamali A, Lieber RL

Effects of muscle contraction on the load-strain properties of frog aponeurosis and tendon.

Lieber RL, Leonard ME, Brown-Maupin CG

Protection of the deltoid to triceps tendon transfer repair sites.

Fridén J, Ejeskär A, Dahlgren A, Lieber RL

Effect of muscle tension during tendon transfer on sarcomerogenesis in a rabbit model.

Fridén J, Pontén E, Lieber RL

Wrist extensor muscle pathology in lateral epicondylitis.

Ljung BO, Lieber RL, Fridén J

Sarcomere length varies with wrist ulnar deviation but not forearm pronation in the extensor carpi radialis brevis muscle.

Ljung BO, Fridén J, Lieber RL

Wrist and digital joint motion produce unique flexor tendon force and excursion in the canine forelimb.

Lieber RL, Silva MJ, Amiel D, Gelberman RH

Transcript-specific mRNA trafficking based on the distribution of coexpressed myosin isoforms.

Shoemaker SD, Ryan AF, Lieber RL

Quantitative analysis of muscle fibre type and myosin heavy chain distribution in the frog hindlimb: implications for locomotory design.

Lutz GJ, Bremner S, Lajevardi N, Lieber RL, Rome LC

Quantification of myosin heavy chain mRNA in somatic and branchial arch muscles using competitive PCR.

Jung HH, Lieber RL, Ryan AF

Segmental muscle fiber lesions after repetitive eccentric contractions.

Fridén J, Lieber RL

Increased oxidative capacity does not protect skeletal muscle fibers from eccentric contraction-induced injury.

Patel TJ, Cuizon D, Mathieu-Costello O, Fridén J, Lieber RL

The role of ulnar nerve transposition in ulnar nerve repair: a cadaver study.

Abrams RA, Fenichel AS, Callahan JJ, Brown RA, Botte MJ, Lieber RL

Simultaneous stiffness and force measurements reveal subtle injury to rabbit soleus muscles.

Benz RJ, Fridén J, Lieber RL

Sarcomere number adaptation after retinaculum transection in adult mice.

Burkholder TJ, Lieber RL

Evidence for muscle attachment at relatively long lengths in tendon transfer surgery.

Fridén J, Lieber RL

Intraoperative measurement and biomechanical modeling of the flexor carpi ulnaris-to-extensor carpi radialis longus tendon transfer.

Lieber RL, Fridén J

Growth hormone secretagogue increases muscle strength during remobilization after canine hindlimb immobilization.

Lieber RL, Jacks TM, Mohler RL, Schleim K, Haven M, Cuizon D, Gershuni DH, Lopez MA, Hora D Jr, Nargund R, Feeney W, Hickey GJ

Sarcomere length in wrist extensor muscles. Changes may provide insights into the etiology of chronic lateral epicondylitis.

Lieber RL, Ljung BO, Fridén J

Anatomy of the radial nerve motor branches in the forearm.

Abrams RA, Ziets RJ, Lieber RL, Botte MJ

Skeletal muscle architecture and fiber-type distribution with the multiple bellies of the mouse extensor digitorum longus muscle.

Chleboun GS, Patel TJ, Lieber RL

Equal effectiveness of electrical and volitional strength training for quadriceps femoris muscles after anterior cruciate ligament surgery.

Lieber RL, Silva PD, Daniel DM

Muscle cytoskeletal disruption occurs within the first 15 min of cyclic eccentric contraction.

Lieber RL, Thornell LE, Fridén J

Anti-inflammatory medication after muscle injury. A treatment resulting in short-term improvement but subsequent loss of muscle function.

Mishra DK, Fridén J, Schmitz MC, Lieber RL

Physiologic consequences of surgical lengthening of extensor carpi radialis brevis muscle-tendon junction for tennis elbow.

Fridén J, Lieber RL

Cloning and in situ hybridization of type 2A and 2B rat skeletal muscle myosin tail region: implications for filament assembly.

Lieber RL, Bodine SC, Burkholder TJ, Pierotti DJ, Ryan AF

Differential effects of 10-Hz and 50 Hz-stimulation of the tibialis anterior on the ipsilateral, unstimulated soleus muscle.

Lieber RL, Ferro TD, Hargens AR

Digital data acquisition and analysis of striated muscle diffraction patterns with a direct memory access microprocessor system.

Roos KP, Baskin RJ, Lieber RL, Cline JW, Paolini PJ

Featured Research

All Publications