Clinical Trial
To evaluate whether transcranial direct current stimulation (tDCS) can improve speech and language therapy outcomes and determine the optimal time to deliver tDCS. The study will determine if it is better to receive tDCS before, during, or after the speech and language therapy session.
Participants must meet the following criteria:
yes
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This is a clinical trial of people who have pain due to knee osteoarthritis at Northwestern University Feinberg School of Medicine in collaboration with Shirley Ryan AbilityLab. The study will last for about 20 weeks. 180 qualified participants will be randomly assigned in a 1:1:1 ratio (60 participants per group) to one of three treatment groups: duloxetine, celecoxib or placebo. Participants will have an X-ray, knee MRI, brain MRI, blood draws, pain sensitivity testing and will be asked to fill out questionnaires. The purpose of this study is to predict which participants will respond to the treatment.
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