Objective
This is a clinical trial of people who have pain due to knee osteoarthritis at Northwestern University Feinberg School of Medicine in collaboration with Shirley Ryan AbilityLab. The study will last for about 20 weeks. 180 qualified participants will be randomly assigned in a 1:1:1 ratio (60 participants per group) to one of three treatment groups: duloxetine, celecoxib or placebo. Participants will have an X-ray, knee MRI, brain MRI, blood draws, pain sensitivity testing and will be asked to fill out questionnaires. The purpose of this study is to predict which participants will respond to the treatment.
Participants will be in this research study for approximately 18-20 weeks, including 5 in-person visits and 6 scheduled phone calls. The study contains two 6-week treatment periods, with a 4-week washout period in between.
Who Can Participate
- Male or female
- Experiencing knee pain
Compensation
$20-75 per visit and travel compensation
Age Range
40-99
