Overview
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Walking recovery is a key goal after spinal cord injury (SCI). While some patients experience spontaneous recovery due to preserved neural circuits, many struggle to achieve independent ambulation, and those who do often face persistent deficits. There is growing consensus that a single approach is insufficient to overcome these challenges, prompting the need for combined interventions.
The goal of this double-blind, placebo-controlled, block-randomized clinical trial is to investigate the efficacy and potency of daily acute intermittent hypoxia (AIH) combined with transcutaneous electrical spinal stimulation (tSTIM) and skill-based walking practice. We hypothesize that the combination of AIH, tSTIM, and walking practice will boost the efficacy of training-related gains without triggering maladaptive changes.
Subject Population
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- Age 18 to 70 years
- Ambulatory incomplete Spinal Cord Injury C2-L2
- ASIA C or D
Study Personnel
Mentioned Profile
Arun Jayaraman, PT, PhD
Executive Director, Technology & Innovation Hub (tiHUB); Director, Max Näder Center for Rehabilitation Technologies & Outcomes ResearchStudy Partners
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This study is in collaboration with the Inspire Lab led by Dr. Randy Trumbower at Spaulding Rehabilitation Hospital.
Funding Source
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Department of Defense
Participation
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